Apps available like nfs hot pursuit and flash videos should be made available free. People using android are getting it for free and still people who trust and buy windows phones are being made to pay again after paying for their phones. Personally it would be bad for business for Microsoft as it is trying to fight android . Asking money for such useful games and apps personally feels like cheating. I hope something is done in this regard soon
Courts ? Gary W. Fotheringham apologizes to victims, blames behavior on alcoholism.
He was raised in a church-going family, the son of a scout leader. But on Friday, a judge ruled that the now-32-year-old man is a danger to society.
Gary W. Fotheringham, who sexually assaulted several women on the University of Utah campus in 2011, was sentenced to up to five years in prison for three counts of attempted forcible sexual abuse. He pleaded guilty to the three charges in June in a deal with prosecutors.
Fotheringham, a tall man with straight brown hair, stood stoically before the judge with his hands cuffed and his legs shackled as she handed down his sentence. He told the court that he?s struggled with alcoholism and has accepted responsibility for what he?s done.
"I would like to apologize for the stress and fear I caused the victims," Fotheringham said. "It?s not their fault; it?s my fault. ? I?m truly sorry."
Judge Katie Bernards-Goodman nodded as she listened to the man?s apology. But it wasn?t enough.
"There are a lot of alcoholics in the world who don?t go out and commit sex offenses," Bernards-Goodman said. "I worry about society and how it would be if I let you go."
She ultimately sided with prosecutors, who argued that Fotheringham was a growing danger to women, and pointed to his criminal behavior, which has escalated over time.
In 2010, University of Utah police arrested Fotheringham for lewdness in a women?s restroom. According to court documents, Fotheringham tried to film a woman in a bathroom stall using his cellphone camera.
A year later, Fotheringham returned to the university, where he "terrorized women," prosecutors said.
No victims were present for Fotheringham?s sentencing, but at a preliminary hearing last year, the women testified against Fotheringham, detailing Nov. 4, 2011 ? a day comprised of a series of escalating sexual assaults.
story continues below
One woman, a U. freshman, said she had just finished changing for an on-campus dance class when she saw a man standing with his back against a wall in the dark hallway outside the women?s locker room. He was peering in at her.
The student said the man later hid in a bathroom stall and, when confronted, told her he thought he was in the men?s room.
A junior at the university testified that she was studying in a building on the campus about 4:30 p.m. when a man crept up behind her as she bent over to pick up her backpack. He put his hand between her legs and groped her, she said.
She said she followed the man, berating him with questions. As he walked away, she said, a pair of underwear fell out of his pocket.
Another student also testified at the preliminary hearing, but was unable to identify Fotheringham as the person who assaulted her.
Police have said Fotheringham?s attacks became more serious over the course of that day, culminating about 8:40 p.m., when Fotheringham followed another woman to her car and groped her as she attempted to get inside.
According to charging documents, Fotheringham tried to cover the woman?s mouth with his hand, but she bit his finger. When officers interviewed Fotheringham in this case, the documents state, he had an injury to one of his fingers.
His attorney, Melissa Fulkerson, asked the judge to allow Fotheringham to stay in Salt Lake County jail for 20 more months to complete a substance abuse treatment program and then be released into the care of his family and his family?s church.
She declined.
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New findings could influence the development of therapies to treat dengue diseasePublic release date: 2-Aug-2013 [ | E-mail | Share ]
Contact: Philippa Walker philippa.walker@bristol.ac.uk 44-117-928-7777 University of Bristol
New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.
The findings, led by researchers at the University of Bristol and published in the Journal of Biological Chemistry today [2 August], show for the first time that there may be significant differences in specific properties of the viral proteins for the four dengue virus types.
Due to the effects of globalisation, including increased travel and urbanisation of human populations and the expanded geographical distribution of the mosquito vector that is responsible for the transmission of viral infections to millions of people, the number of individuals afflicted with dengue is rising.
Infection with any one of the four types of dengue virus (DENV types 1 - 4) may result in a spectrum of illnesses ranging from dengue fever, a mild flu like illness which causes high fever and joint pains, to the potentially fatal dengue haemorrhagic fever. Despite intensive research, dengue disease is not wholly understood, and there are no vaccines or anti-viral treatments available that can safely or effectively control the disease.
Dr Andrew Davidson, Senior Virologist and lead researcher from the University of Bristol, and colleagues examined the nuclear localisation properties of the NS5 protein of all four DENV types and found that there are major differences in the cellular localisation of the viral NS5 protein for the four DENV types.
The four types of DENV are genetically distinct. Although they can all cause dengue disease, little is known about how the genetic differences between them may translate into differences in virus replication and pathogenesis.
Previous studies by the team focusing on DENV-2, have shown that the viral NS5 protein is essential for DENV genome replication and is able to modulate the host immune response. As such, the NS5 protein is a key target for the development of anti-viral agents. Importantly, the team also showed that the DENV-2 NS5 protein accumulates in the nucleus during infection which is believed to effect host cell function.
Dr Davidson, Senior Lecturer in Virology, School of Cellular and Molecular Medicine at the University of Bristol, said: "The study shows for the first time that there may be significant differences in specific properties of the viral proteins for the four DENV types. This is important as it impacts on our understanding of viral replication and pathogenesis and the design of anti-viral therapies that are effective against all DENV types."
Present studies in the laboratory are focused on comprehensively comparing the effects of different DENV types on the host cell, using the state-of-the-art proteomics facilities at the University of Bristol.
###
Further information
Paper
The paper, entitled 'Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization' is published in the Journal of Biological Chemistry, Vol. 288, Issue 31, 22621-22635, August 2, 2013.
Holger Hannemann (University of Bristol); Po-Yu Sung (University of Bristol); Han-Chen Chiu (University of Bristol); Amjad Yousuf (University of Bristol and Taif University); Jim Bird (University of Bristol); Andrew D. Davidson (University of Bristol) and Siew Pheng Lim(Novartis Institute for Tropical Diseases).
Dengue
Dengue is a mosquito-borne infection found in tropical and sub-tropical regions around the world. In recent years, transmission has increased predominantly in urban and semi-urban areas and has become a major international public health concern.
Dengue is a mosquito-borne viral infection.
The infection causes flu-like illness, and occasionally develops into a potentially lethal complication called severe dengue.
The global incidence of dengue has grown dramatically in recent decades.
About half of the world's population is now at risk.
Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas.
Severe dengue is a leading cause of serious illness and death among children in some Asian and Latin American countries.
There is no specific treatment for dengue/ severe dengue, but early detection and access to proper medical care lowers fatality rates below 1 per cent.
Dengue prevention and control solely depends on effective vector control measures.
Source: WHO
Notes to editors
For more information or to arrange an interview with Dr Andrew Davidson, please contact the University of Bristol Press Office, tel. +44 (0) 117 928 8086, tel mobile. +44 (0)7776 170238, email. Press-office@bristol.ac.uk
Paper
An advance copy of the paper is available to download from the below URL
https://fluff.bris.ac.uk/fluff/u3/ficmc/xBhVeusEDrKVQrVlbvJIZQGx5/
Issued by the Public Relations Office, Marketing & Communications Division, University of Bristol
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
New findings could influence the development of therapies to treat dengue diseasePublic release date: 2-Aug-2013 [ | E-mail | Share ]
Contact: Philippa Walker philippa.walker@bristol.ac.uk 44-117-928-7777 University of Bristol
New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.
The findings, led by researchers at the University of Bristol and published in the Journal of Biological Chemistry today [2 August], show for the first time that there may be significant differences in specific properties of the viral proteins for the four dengue virus types.
Due to the effects of globalisation, including increased travel and urbanisation of human populations and the expanded geographical distribution of the mosquito vector that is responsible for the transmission of viral infections to millions of people, the number of individuals afflicted with dengue is rising.
Infection with any one of the four types of dengue virus (DENV types 1 - 4) may result in a spectrum of illnesses ranging from dengue fever, a mild flu like illness which causes high fever and joint pains, to the potentially fatal dengue haemorrhagic fever. Despite intensive research, dengue disease is not wholly understood, and there are no vaccines or anti-viral treatments available that can safely or effectively control the disease.
Dr Andrew Davidson, Senior Virologist and lead researcher from the University of Bristol, and colleagues examined the nuclear localisation properties of the NS5 protein of all four DENV types and found that there are major differences in the cellular localisation of the viral NS5 protein for the four DENV types.
The four types of DENV are genetically distinct. Although they can all cause dengue disease, little is known about how the genetic differences between them may translate into differences in virus replication and pathogenesis.
Previous studies by the team focusing on DENV-2, have shown that the viral NS5 protein is essential for DENV genome replication and is able to modulate the host immune response. As such, the NS5 protein is a key target for the development of anti-viral agents. Importantly, the team also showed that the DENV-2 NS5 protein accumulates in the nucleus during infection which is believed to effect host cell function.
Dr Davidson, Senior Lecturer in Virology, School of Cellular and Molecular Medicine at the University of Bristol, said: "The study shows for the first time that there may be significant differences in specific properties of the viral proteins for the four DENV types. This is important as it impacts on our understanding of viral replication and pathogenesis and the design of anti-viral therapies that are effective against all DENV types."
Present studies in the laboratory are focused on comprehensively comparing the effects of different DENV types on the host cell, using the state-of-the-art proteomics facilities at the University of Bristol.
###
Further information
Paper
The paper, entitled 'Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization' is published in the Journal of Biological Chemistry, Vol. 288, Issue 31, 22621-22635, August 2, 2013.
Holger Hannemann (University of Bristol); Po-Yu Sung (University of Bristol); Han-Chen Chiu (University of Bristol); Amjad Yousuf (University of Bristol and Taif University); Jim Bird (University of Bristol); Andrew D. Davidson (University of Bristol) and Siew Pheng Lim(Novartis Institute for Tropical Diseases).
Dengue
Dengue is a mosquito-borne infection found in tropical and sub-tropical regions around the world. In recent years, transmission has increased predominantly in urban and semi-urban areas and has become a major international public health concern.
Dengue is a mosquito-borne viral infection.
The infection causes flu-like illness, and occasionally develops into a potentially lethal complication called severe dengue.
The global incidence of dengue has grown dramatically in recent decades.
About half of the world's population is now at risk.
Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas.
Severe dengue is a leading cause of serious illness and death among children in some Asian and Latin American countries.
There is no specific treatment for dengue/ severe dengue, but early detection and access to proper medical care lowers fatality rates below 1 per cent.
Dengue prevention and control solely depends on effective vector control measures.
Source: WHO
Notes to editors
For more information or to arrange an interview with Dr Andrew Davidson, please contact the University of Bristol Press Office, tel. +44 (0) 117 928 8086, tel mobile. +44 (0)7776 170238, email. Press-office@bristol.ac.uk
Paper
An advance copy of the paper is available to download from the below URL
https://fluff.bris.ac.uk/fluff/u3/ficmc/xBhVeusEDrKVQrVlbvJIZQGx5/
Issued by the Public Relations Office, Marketing & Communications Division, University of Bristol
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
A new model can predict a woman's risk of breast, ovarian and womb cancerPublic release date: 30-Jul-2013 [ | E-mail | Share ]
Contact: Fiona Godwin fgodwin@plos.org 01-223-442-834 Public Library of Science
The probability (absolute risk) of a woman developing breast, ovarian, and endometrial (womb) cancer can all be predicted using easily obtainable information on known risk factors for these cancers, according to a study by US researchers published in this week's PLOS Medicine.
Ruth Pfeiffer from the National Cancer Institute in Bethesda, USA and colleagues from institutions throughout the US, developed statistical models based on risk factors of these three common cancers that could help with clinical decision making.
The authors developed these models by using information from two large US studies that included white, non-Hispanic women aged over 50 years and by including commonly known risk factors, such as parity (the number of children a women delivered), body mass index (an indicator of the amount of body fat), use of oral contraceptives, and menopausal status and use of menopausal hormone therapy. The resulting models were able to predict individual women's risk of each cancer: for example, individual women's risk for endometrial cancer calculated using this model ranged from 0.5% to 29.5% over the next 20 years depending on their exposure to various risk factors.
The authors say: "These models predict absolute risks for breast, endometrial, and ovarian cancers from easily obtainable risk factors and may assist in clinical decision-making."
They add: "Limitations are the modest discriminatory ability of the breast and ovarian models and that these models may not generalize to women of other races."
In an accompanying Perspective, Lars Holmberg from Uppsala University Hospital in Sweden and Andrew Vickers from the Memorial Sloan-Kettering Cancer Center in New York (uninvolved in the study) support the focus of the model on helping with clinical-decision making and say: "Ruth Pfeiffer and colleagues present models for absolute risks and thereby avoid the common mistake of proclaiming a substantial relative risk as clinically relevant without considering the background risk."
###
Research Article
Funding: The manuscript was developed with support from the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
Citation: Pfeiffer RM, Park Y, Kreimer AR, Lacey JV Jr, Pee D, et al. (2013) Risk Prediction for Breast, Endometrial, and Ovarian Cancer in White Women Aged 50 y or Older: Derivation and Validation from Population-Based Cohort Studies. PLoS Med 10(7): e1001492. doi:10.1371/journal.pmed.1001492
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:
Office of Media Relations
National Cancer Institute
UNITED STATES
ncipressofficers@mail.nih.gov
Perspective Article
Funding: No specific funding was received to write this article.
Competing Interests: The authors declare no competing interests.
Citation: Holmberg L, Vickers A (2013) Evaluation of Prediction Models for Decision-Making: Beyond Calibration and Discrimination. PLoS Med 10(7): e1001491. doi:10.1371/journal.pmed.1001491
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:
Lars Holmberg
Medical School, King's College London
Division of Cancer Studies
UNITED KINGDOM
+44 (0)20 7188 7904
lars.holmberg@kcl.ac.uk
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
A new model can predict a woman's risk of breast, ovarian and womb cancerPublic release date: 30-Jul-2013 [ | E-mail | Share ]
Contact: Fiona Godwin fgodwin@plos.org 01-223-442-834 Public Library of Science
The probability (absolute risk) of a woman developing breast, ovarian, and endometrial (womb) cancer can all be predicted using easily obtainable information on known risk factors for these cancers, according to a study by US researchers published in this week's PLOS Medicine.
Ruth Pfeiffer from the National Cancer Institute in Bethesda, USA and colleagues from institutions throughout the US, developed statistical models based on risk factors of these three common cancers that could help with clinical decision making.
The authors developed these models by using information from two large US studies that included white, non-Hispanic women aged over 50 years and by including commonly known risk factors, such as parity (the number of children a women delivered), body mass index (an indicator of the amount of body fat), use of oral contraceptives, and menopausal status and use of menopausal hormone therapy. The resulting models were able to predict individual women's risk of each cancer: for example, individual women's risk for endometrial cancer calculated using this model ranged from 0.5% to 29.5% over the next 20 years depending on their exposure to various risk factors.
The authors say: "These models predict absolute risks for breast, endometrial, and ovarian cancers from easily obtainable risk factors and may assist in clinical decision-making."
They add: "Limitations are the modest discriminatory ability of the breast and ovarian models and that these models may not generalize to women of other races."
In an accompanying Perspective, Lars Holmberg from Uppsala University Hospital in Sweden and Andrew Vickers from the Memorial Sloan-Kettering Cancer Center in New York (uninvolved in the study) support the focus of the model on helping with clinical-decision making and say: "Ruth Pfeiffer and colleagues present models for absolute risks and thereby avoid the common mistake of proclaiming a substantial relative risk as clinically relevant without considering the background risk."
###
Research Article
Funding: The manuscript was developed with support from the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. No funding bodies had any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
Citation: Pfeiffer RM, Park Y, Kreimer AR, Lacey JV Jr, Pee D, et al. (2013) Risk Prediction for Breast, Endometrial, and Ovarian Cancer in White Women Aged 50 y or Older: Derivation and Validation from Population-Based Cohort Studies. PLoS Med 10(7): e1001492. doi:10.1371/journal.pmed.1001492
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:
Office of Media Relations
National Cancer Institute
UNITED STATES
ncipressofficers@mail.nih.gov
Perspective Article
Funding: No specific funding was received to write this article.
Competing Interests: The authors declare no competing interests.
Citation: Holmberg L, Vickers A (2013) Evaluation of Prediction Models for Decision-Making: Beyond Calibration and Discrimination. PLoS Med 10(7): e1001491. doi:10.1371/journal.pmed.1001491
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:
Lars Holmberg
Medical School, King's College London
Division of Cancer Studies
UNITED KINGDOM
+44 (0)20 7188 7904
lars.holmberg@kcl.ac.uk
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
[unable to retrieve full-text content]A new study shows that families can save hundreds if not thousands of dollars by making their own household items with a 3-D printer.
Leon Washington is ready to do more than just return kicks and punts for the New England Patriots.
But if that?s all the free agent signee gets to do for his new team, he sounds ready to live with it.
?Ever since I was a rookie, I was always a team player,? Washington said Sunday, after the team?s first full-pads practice. ?That?s been my main focus. Knowing I could so many different things well -- running the ball, catching the ball, returning kicks, (I) even made tackles (on special teams) sometimes in my career.
?That?s the same approach I have here - coming in, helping the team out the best way I can.?
Washington, now 31, debuted with the New York Jets and played the last three seasons with Seattle. A 98-yard kick return for a touchdown last year gave him eight kick return TDs in his seven-year career, tying him with Josh Cribbs for the NFL record.
With Danny Woodhead leaving the Patriots for San Diego, there?s an opening for an all-purpose third-down back in New England. Shane Vereen will likely get most of that work and there?s a chance Washington won?t get much time.
?He?s played back there before but not a lot recently with the Seahawks,? Belichick said. ?We?ll put him in our system, teach him the things that he needs to learn at that position, evaluate him with the other players.?
Washington?s offensive plays indeed dwindled the last two years. Asked if that was disappointing, though, he said, ?No, not really.
?Obviously, I?m a competitor and want to be on the football field, want to be out there and help the team out as much as I can. But not really - we won a bunch of games when I was in Seattle, being a team player is the most important thing.?
He said he came to New England for the ?obvious? reasons.
?You watch this organization from afar, you see how well they do things here,? he said. ?It?s a winning organization. They believe in winning, they believe in competing.
?The most important thing that I love, that I?ve seen so far, is everybody is all about the team. Everybody is going to do whatever they do to help the team win. That?s impressive, watching it from afar. Everything when they guys come out and compete, hear them talking to the media, hear guys talking in the weight room, everything is all about the team.?
Belichick said the first day in pads is the start of the evaluation process of the bigger players on the team - the tacklers and blockers.
?It feels great,? said veteran guard Logan Mankins, who spent much of his morning dealing with Vince Wilfork on the other side of the line. ?Pretty tired right now but it?s always nice to start playing real football - to see where you?re at where you need to go.?
Wilfork stripped Stevan Ridley of the ball in a goal-line situation, one of two fumbles by Ridley on the day. (Jerod Mayo snared the other one out of the air), which led to some extra running for the back.
Notes
Tim Tebow was a bit better on Day 3 - hardly perfect, but better -- connecting on a pair of long touchdown passes. . Tom Brady had a pass intercepted by Kyle Arrington. . Rookie wide receiver Aaron Dobson had another strong day and fellow rookie Josh Boyce made his first impression. . Actor Robert Duvall, who has visited the Whitey Bulger murder trial, was at camp chatting with New England owner Robert Kraft. Also spotted: former Pats Troy Brown and Christian Fouria. . Belichick said defensive end Armond Armstead is on the non-football illness list for something not related to previous heart problems. . Linebacker Dane Fletcher, who missed all last season with a knee injury, is on the field. ?I don?t think he?s had any physical limitations to what we?ve done,? Belichick said. . The quarterbacks have video cameras attached to their helmets, another evaluation tool. ?We?ll take a look at it and see what we get out of it,? Belichick said. . Former linebacker Tedy Bruschi and retiring broadcaster Gil Santos will enter the team?s Hall of Fame before Monday night?s practice.
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Public release date: 2-Aug-2013
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