Apps available like nfs hot pursuit and flash videos should be made available free. People using android are getting it for free and still people who trust and buy windows phones are being made to pay again after paying for their phones. Personally it would be bad for business for Microsoft as it is trying to fight android . Asking money for such useful games and apps personally feels like cheating. I hope something is done in this regard soon
Courts ? Gary W. Fotheringham apologizes to victims, blames behavior on alcoholism.
He was raised in a church-going family, the son of a scout leader. But on Friday, a judge ruled that the now-32-year-old man is a danger to society.
Gary W. Fotheringham, who sexually assaulted several women on the University of Utah campus in 2011, was sentenced to up to five years in prison for three counts of attempted forcible sexual abuse. He pleaded guilty to the three charges in June in a deal with prosecutors.
Fotheringham, a tall man with straight brown hair, stood stoically before the judge with his hands cuffed and his legs shackled as she handed down his sentence. He told the court that he?s struggled with alcoholism and has accepted responsibility for what he?s done.
"I would like to apologize for the stress and fear I caused the victims," Fotheringham said. "It?s not their fault; it?s my fault. ? I?m truly sorry."
Judge Katie Bernards-Goodman nodded as she listened to the man?s apology. But it wasn?t enough.
"There are a lot of alcoholics in the world who don?t go out and commit sex offenses," Bernards-Goodman said. "I worry about society and how it would be if I let you go."
She ultimately sided with prosecutors, who argued that Fotheringham was a growing danger to women, and pointed to his criminal behavior, which has escalated over time.
In 2010, University of Utah police arrested Fotheringham for lewdness in a women?s restroom. According to court documents, Fotheringham tried to film a woman in a bathroom stall using his cellphone camera.
A year later, Fotheringham returned to the university, where he "terrorized women," prosecutors said.
No victims were present for Fotheringham?s sentencing, but at a preliminary hearing last year, the women testified against Fotheringham, detailing Nov. 4, 2011 ? a day comprised of a series of escalating sexual assaults.
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One woman, a U. freshman, said she had just finished changing for an on-campus dance class when she saw a man standing with his back against a wall in the dark hallway outside the women?s locker room. He was peering in at her.
The student said the man later hid in a bathroom stall and, when confronted, told her he thought he was in the men?s room.
A junior at the university testified that she was studying in a building on the campus about 4:30 p.m. when a man crept up behind her as she bent over to pick up her backpack. He put his hand between her legs and groped her, she said.
She said she followed the man, berating him with questions. As he walked away, she said, a pair of underwear fell out of his pocket.
Another student also testified at the preliminary hearing, but was unable to identify Fotheringham as the person who assaulted her.
Police have said Fotheringham?s attacks became more serious over the course of that day, culminating about 8:40 p.m., when Fotheringham followed another woman to her car and groped her as she attempted to get inside.
According to charging documents, Fotheringham tried to cover the woman?s mouth with his hand, but she bit his finger. When officers interviewed Fotheringham in this case, the documents state, he had an injury to one of his fingers.
His attorney, Melissa Fulkerson, asked the judge to allow Fotheringham to stay in Salt Lake County jail for 20 more months to complete a substance abuse treatment program and then be released into the care of his family and his family?s church.
She declined.
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New findings could influence the development of therapies to treat dengue diseasePublic release date: 2-Aug-2013 [ | E-mail | Share ]
Contact: Philippa Walker philippa.walker@bristol.ac.uk 44-117-928-7777 University of Bristol
New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.
The findings, led by researchers at the University of Bristol and published in the Journal of Biological Chemistry today [2 August], show for the first time that there may be significant differences in specific properties of the viral proteins for the four dengue virus types.
Due to the effects of globalisation, including increased travel and urbanisation of human populations and the expanded geographical distribution of the mosquito vector that is responsible for the transmission of viral infections to millions of people, the number of individuals afflicted with dengue is rising.
Infection with any one of the four types of dengue virus (DENV types 1 - 4) may result in a spectrum of illnesses ranging from dengue fever, a mild flu like illness which causes high fever and joint pains, to the potentially fatal dengue haemorrhagic fever. Despite intensive research, dengue disease is not wholly understood, and there are no vaccines or anti-viral treatments available that can safely or effectively control the disease.
Dr Andrew Davidson, Senior Virologist and lead researcher from the University of Bristol, and colleagues examined the nuclear localisation properties of the NS5 protein of all four DENV types and found that there are major differences in the cellular localisation of the viral NS5 protein for the four DENV types.
The four types of DENV are genetically distinct. Although they can all cause dengue disease, little is known about how the genetic differences between them may translate into differences in virus replication and pathogenesis.
Previous studies by the team focusing on DENV-2, have shown that the viral NS5 protein is essential for DENV genome replication and is able to modulate the host immune response. As such, the NS5 protein is a key target for the development of anti-viral agents. Importantly, the team also showed that the DENV-2 NS5 protein accumulates in the nucleus during infection which is believed to effect host cell function.
Dr Davidson, Senior Lecturer in Virology, School of Cellular and Molecular Medicine at the University of Bristol, said: "The study shows for the first time that there may be significant differences in specific properties of the viral proteins for the four DENV types. This is important as it impacts on our understanding of viral replication and pathogenesis and the design of anti-viral therapies that are effective against all DENV types."
Present studies in the laboratory are focused on comprehensively comparing the effects of different DENV types on the host cell, using the state-of-the-art proteomics facilities at the University of Bristol.
###
Further information
Paper
The paper, entitled 'Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization' is published in the Journal of Biological Chemistry, Vol. 288, Issue 31, 22621-22635, August 2, 2013.
Holger Hannemann (University of Bristol); Po-Yu Sung (University of Bristol); Han-Chen Chiu (University of Bristol); Amjad Yousuf (University of Bristol and Taif University); Jim Bird (University of Bristol); Andrew D. Davidson (University of Bristol) and Siew Pheng Lim(Novartis Institute for Tropical Diseases).
Dengue
Dengue is a mosquito-borne infection found in tropical and sub-tropical regions around the world. In recent years, transmission has increased predominantly in urban and semi-urban areas and has become a major international public health concern.
Dengue is a mosquito-borne viral infection.
The infection causes flu-like illness, and occasionally develops into a potentially lethal complication called severe dengue.
The global incidence of dengue has grown dramatically in recent decades.
About half of the world's population is now at risk.
Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas.
Severe dengue is a leading cause of serious illness and death among children in some Asian and Latin American countries.
There is no specific treatment for dengue/ severe dengue, but early detection and access to proper medical care lowers fatality rates below 1 per cent.
Dengue prevention and control solely depends on effective vector control measures.
Source: WHO
Notes to editors
For more information or to arrange an interview with Dr Andrew Davidson, please contact the University of Bristol Press Office, tel. +44 (0) 117 928 8086, tel mobile. +44 (0)7776 170238, email. Press-office@bristol.ac.uk
Paper
An advance copy of the paper is available to download from the below URL
https://fluff.bris.ac.uk/fluff/u3/ficmc/xBhVeusEDrKVQrVlbvJIZQGx5/
Issued by the Public Relations Office, Marketing & Communications Division, University of Bristol
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
New findings could influence the development of therapies to treat dengue diseasePublic release date: 2-Aug-2013 [ | E-mail | Share ]
Contact: Philippa Walker philippa.walker@bristol.ac.uk 44-117-928-7777 University of Bristol
New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.
The findings, led by researchers at the University of Bristol and published in the Journal of Biological Chemistry today [2 August], show for the first time that there may be significant differences in specific properties of the viral proteins for the four dengue virus types.
Due to the effects of globalisation, including increased travel and urbanisation of human populations and the expanded geographical distribution of the mosquito vector that is responsible for the transmission of viral infections to millions of people, the number of individuals afflicted with dengue is rising.
Infection with any one of the four types of dengue virus (DENV types 1 - 4) may result in a spectrum of illnesses ranging from dengue fever, a mild flu like illness which causes high fever and joint pains, to the potentially fatal dengue haemorrhagic fever. Despite intensive research, dengue disease is not wholly understood, and there are no vaccines or anti-viral treatments available that can safely or effectively control the disease.
Dr Andrew Davidson, Senior Virologist and lead researcher from the University of Bristol, and colleagues examined the nuclear localisation properties of the NS5 protein of all four DENV types and found that there are major differences in the cellular localisation of the viral NS5 protein for the four DENV types.
The four types of DENV are genetically distinct. Although they can all cause dengue disease, little is known about how the genetic differences between them may translate into differences in virus replication and pathogenesis.
Previous studies by the team focusing on DENV-2, have shown that the viral NS5 protein is essential for DENV genome replication and is able to modulate the host immune response. As such, the NS5 protein is a key target for the development of anti-viral agents. Importantly, the team also showed that the DENV-2 NS5 protein accumulates in the nucleus during infection which is believed to effect host cell function.
Dr Davidson, Senior Lecturer in Virology, School of Cellular and Molecular Medicine at the University of Bristol, said: "The study shows for the first time that there may be significant differences in specific properties of the viral proteins for the four DENV types. This is important as it impacts on our understanding of viral replication and pathogenesis and the design of anti-viral therapies that are effective against all DENV types."
Present studies in the laboratory are focused on comprehensively comparing the effects of different DENV types on the host cell, using the state-of-the-art proteomics facilities at the University of Bristol.
###
Further information
Paper
The paper, entitled 'Serotype-specific Differences in Dengue Virus Non-structural Protein 5 Nuclear Localization' is published in the Journal of Biological Chemistry, Vol. 288, Issue 31, 22621-22635, August 2, 2013.
Holger Hannemann (University of Bristol); Po-Yu Sung (University of Bristol); Han-Chen Chiu (University of Bristol); Amjad Yousuf (University of Bristol and Taif University); Jim Bird (University of Bristol); Andrew D. Davidson (University of Bristol) and Siew Pheng Lim(Novartis Institute for Tropical Diseases).
Dengue
Dengue is a mosquito-borne infection found in tropical and sub-tropical regions around the world. In recent years, transmission has increased predominantly in urban and semi-urban areas and has become a major international public health concern.
Dengue is a mosquito-borne viral infection.
The infection causes flu-like illness, and occasionally develops into a potentially lethal complication called severe dengue.
The global incidence of dengue has grown dramatically in recent decades.
About half of the world's population is now at risk.
Dengue is found in tropical and sub-tropical climates worldwide, mostly in urban and semi-urban areas.
Severe dengue is a leading cause of serious illness and death among children in some Asian and Latin American countries.
There is no specific treatment for dengue/ severe dengue, but early detection and access to proper medical care lowers fatality rates below 1 per cent.
Dengue prevention and control solely depends on effective vector control measures.
Source: WHO
Notes to editors
For more information or to arrange an interview with Dr Andrew Davidson, please contact the University of Bristol Press Office, tel. +44 (0) 117 928 8086, tel mobile. +44 (0)7776 170238, email. Press-office@bristol.ac.uk
Paper
An advance copy of the paper is available to download from the below URL
https://fluff.bris.ac.uk/fluff/u3/ficmc/xBhVeusEDrKVQrVlbvJIZQGx5/
Issued by the Public Relations Office, Marketing & Communications Division, University of Bristol
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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